[PSI(+)] yeast, containing the misfolded amyloid conformation of Sup35 prion, is cured by inactivation of Hsp104.There has been controversy as to whether inactivation of Hsp104 by guanidine treatment or by overexpression of the dominant negative Hsp104 mutant, Hsp104-2KT, cures [PSI(+)] by the same Tools and Templates mechanism- inhibition of the s
Background/Aims: Nexrutine is an herbal extract of Phellodendron amurense and has been used as nutrient supplement in China as well as America.Potential protection effect of Nexrutine has been reported.Methods: To investigate the mechanism of Nexrutine, we used the HeLa, U2OS and HCT116 as a model.Based on the acidification of cell culture media, w
The causes and contributing factors of autism spectrum disorders (ASD) are poorly understood.One gene associated with increased risk for ASD is methylenetetrahydrofolate-reductase (MTHFR), which encodes a key enzyme in one carbon (C1) metabolism.The MTHFR 677C > T polymorphism reduces the efficiency of methyl group production with possible adver
Ahead of her time and outside of her assigned place, Adrienne Herndon achieved acclaim in education, drama, and architecture in turn-of-the-century Atlanta.As head of BOW TIE the drama department at Atlanta University, as aspiring dramatic artist, as architect of what would be designated a National Historic Landmark, Adrienne Herndon set her own co
Given the problem of three-sources uncertainty in aero engine degradation process and the assumption of normal distribution of measurement error in existing research, a Wiener process aero engine residual useful life time(RUL) prediction method with logistic distribution of measurement error was proposed.Firstly, the performance degradation model w